And both Bezzecchi and then Martin fell in separate incidents at the same Turn 16.
Incredible! Both Bezzecchi and Martin have a golden opportunity to take big points off Bagnaia, if they qualify well, but are now running back for their spare bikes!
Now Jorge Martin is down!
An early fall for another title contender, Marco Bezzecchi, the already injured VR46 rider suffers his second accident of the weekend. Fortunately, his fractured collarbone appears unharmed as he runs out of the gravel trap.
All eyes are now on Jorge Martin to see how much he can exploit Bagnaia's Qualifying 1 woes.
Qualifying 2 begins, with Marini and Bastianini joining the ten fastest riders from Friday afternoon.
Bagnaia walks straight out of the factory Ducati garage.
Session over: Luca Marini and Enea Bastianini progress to Qualifying 2.
Zarco suffers a fast fall at the end of the session.
Bagnaia shakes his head in disbelief as he sees the results on the big screen. He will start just 13th on the grid in the Sprint and Sunday races.
That could be it! Bagnaia has backed off. Shocked faces in the Ducati pits....
Enea Bastianini pushes team-mate Bagnaia out of the top 2!
Bagnaia goes fastest on his next lap, but is pushed to second moments later by Marini.
2mins to go.
Bagnaia's first flyer is not good enough. He's still third behind Zarco and Morbidelli.
Jack Appleyard reports from pit lane that the tyre data was wrong, Bagnaia is on new tyres.
The Ducati team are keeping calm but the tension is palpable. Bagnaia has a real fight on his hands and - surprisingly - the timing data says he has gone out on used tyres!
If that is true it means Bagnaia would still have 2 new soft tyres if he gets through to Qualifying 2... but first, he has to get through.
It could be a tyre data error on the screens.
Meanwhile, title rival Jorge Martin looks on as an interested observer.
Bastianini is annoyed to catch Bagnaia and Mir after they had backed off.
5mins gone and it's Johann Zarco and Morbidelli holding the transfer places, Bagnaia and Marini follow.
Joan Mir and Franco Morbidelli are chasing Bagnaia in the early stages of Qualifying 1.
Simon Crafar on the importance of Bagnaia getting through Qualifying 1: "If Pecco doesn't pull this off, he's probably going to lose the lead of the world championship [this weekend]."
With such a narrow (clean) racing line, it'll be more important than ever for title leader Francesco Bagnaia to progress through Qualifying 1.
Qualifying 1 line-up:
Pol Espargaro
Luca Marini
Johann Zarco
Raul Fernandez
Franco Morbidelli
Francesco Bagnaia
Takaaki Nakagami
Augusto Fernandez
Joan Mir
Enea Bastianini
Alex Rins
Jorge Martin leads final practice from Aleix Espargaro and Maverick Vinales. Qualifying 1 next!
The top 10 is covered by just over half-a-second but it's been a slow start to the morning for the Repsol Hondas with Marquez and Mir in 19th and 20th.