Marc Marquez out of Indonesian MotoGP after colossal accident
Hospital checks subsequently revealed the Spaniard suffered a 'head concussion'.
Horrendous weather conditions threatened the race but, after a lengthy delay, it was won by KTM's Miguel Oliveira.
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Marquez was in hospital when the race finally got underway.
"It's been strange because Marc had three big crashes and we have to understand why," Repsol Honda team manager Alberto Puig told Dorna's Simon Crafar.
"The crash today was brutal. We need to anaylse. They [Michelin] brought a different tyre here and we need to understand everything. Our rider crashed and we want to understand [why]."
The eight-time world champion, who has missed half of the races held since the start of 2020 due to arm and eye injuries, suffered the biggest highside of his career when the rear tyre kicked out at just under 200km/h.
SHOCKING highside for @marcmarquez93!
— MotoGP (@MotoGP) March 20, 2022
Incredibly Marc was able to walk away and hopefully he's all OK #IndonesianGP pic.twitter.com/uUwWxQJvHa
Like all the Honda riders, Marquez has been battling a lack of grip from the modified Michelin rear tyre casing all weekend, falling three times and saving many other sideways moments.
That included an earlier scare, on the soft rear, in warm-up.
But there was no stopping the horror Turn 7 highside, when the rear tyre (almost new) lost traction off-throttle before biting and launching Marquez into the sky.
The Spaniard's Buriram highside was similar, but that occurred on an out-lap, whereas this was at full-speed through one of the fastest sections of the track.
Marquez's previous injuries meant there was heightened concern for his welfare and considerable relief when he eventually got to his feet. But the 29-year-old was clearly struggling in the aftermath, staggering and pausing as he walked slowly out of the gravel.
Fortunately, Marquez returned to the paddock on the back of a scooter, rather than an ambulance, before heading for the Medical Centre. Unsurprisingly given the violence of the incident, Marquez was then sent to a local hospital for further checks, which diagnosed the concussion.
Fifth in the Qatar season-opener, Marquez had been due to start the shortened race (due to problems with the track surface) from 14th place, as top Honda.
But will there even be a race?
Torrential rain is pouring down at Mandalika, the kind of conditions that saw a WorldSBK race cancelled last November. The MotoGP start has been delayed.
Marquez admitted on Saturday that he would have prefer a wet race in performance terms, due to Honda's tyre problems in the dry.